The Bills used a balanced offensive attack and another good defensive effort to beat the lowly Colts. Doug Flutie got his "magic" back as he completed 20 of 28 passes for 230 yards. The running game was led by Antowain Smith who had his fourth career 100 yard game, three of them against Indianapolis. Smith scored two touchdowns and average 4.7 yards a carry. The defense contributed to the rout by picking off two passes as well as pulling off a textbook goal line stand in the third quarter

The Bills struggled in the first quarter with bad calls and dumb penalties as the Colts took a 3-0 lead. Kevin Williams made a great catch and stayed on his feet as he ran the distance for a touchdown on the first possession, but the refs ruled he was down. Thurman Thomas also had a touchdown catch on a screen pass called back by an illegal man downfield penalty on Dusty Ziegler.

The game turned late in the first quarter on Ken Irvin's interception that set up Sam Gash's TD reception early in the second quarter. Antowain Smith's first TD and a vintage Andre Reed catch and run capped off three straight touchdown drives in the quarter. The Bills capped out the half by turning a Kurt Schultz interception into three points.

With this game being a laugher Wade Phillips emptied his bench. Rob Johnson saw some action and was promptly sacked running toward the sidelines. Rookie Johnathon Linton averaged nearly 8 yards per carry subbing for Smith. The newest bill Wayne Simmons came in for one play and made the tackle.